{"id":188811,"date":"2026-02-19T06:50:00","date_gmt":"2026-02-19T11:50:00","guid":{"rendered":"https:\/\/testing.news-you-need.com\/index.php\/2026\/02\/19\/evaluation-of-artificial-intelligence-identified-ipratropium-bromide-for-the-treatment-of-coronavirus-disease-2019\/"},"modified":"2026-02-19T07:30:13","modified_gmt":"2026-02-19T12:30:13","slug":"evaluation-of-artificial-intelligence-identified-ipratropium-bromide-for-the-treatment-of-coronavirus-disease-2019","status":"publish","type":"post","link":"https:\/\/testing.news-you-need.com\/index.php\/2026\/02\/19\/evaluation-of-artificial-intelligence-identified-ipratropium-bromide-for-the-treatment-of-coronavirus-disease-2019\/","title":{"rendered":"Evaluation of artificial intelligence identified ipratropium bromide for the treatment of coronavirus disease 2019"},"content":{"rendered":"<p><a href=\"https:\/\/www.nature.com\/articles\/s41598-025-27869-y\">Evaluation of artificial intelligence identified ipratropium bromide for the treatment of coronavirus disease 2019<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41598-025-27869-y\">https:\/\/www.nature.com\/articles\/s41598-025-27869-y<\/a><\/p>\n<p>Publish Date: <a href=\"publish_date]\">2026-02-19 06:50:00<\/a><\/p>\n<p>Source Domain: <a href=\"www.nature.com\">www.nature.com<\/a><\/p>\n<p>Here&#8217;s an unordered list summarizing the key points of the study:<\/p>\n<ul>\n<li>\n<p><strong>Ethics Approval<\/strong>: The study received Institutional Review Board and Animal Care and Use Committee approvals, as well as informed consent from all participants in accordance with the principles of the Declaration of Helsinki.<\/p>\n<\/li>\n<li>\n<p><strong>Patient Enrollment<\/strong>: Eighteen COVID-19 patients (eight mild and ten severe) were enrolled from February 2020 to January 2021 in South Korea, with severity assessed based on WHO criteria.<\/p>\n<\/li>\n<li>\n<p><strong>Drug Screening<\/strong>: Researchers used the RAPTOR AI platform, combined with transcriptomic data from 23,277 chemicals, to screen for potential treatments based on gene expression in patient samples.<\/p>\n<\/li>\n<li>\n<p><strong>Animal Model<\/strong>: Efficacy of treatments (remdesivir, ipratropium bromide) was tested on SH101 hamsters infected with SARS-CoV-2.<\/p>\n<\/li>\n<li>\n<p><strong>Outcome Assessments<\/strong>: Clinical observations in hamsters included body weight, temperature, and blood analysis for inflammatory markers, along with histopathological examination and quantification of viral RNA in lung tissue.<\/p>\n<\/li>\n<li>\n<p><strong>Therapeutic Efficacy<\/strong>: Both remdesivir and ipratropium bromide treatments showed efficacy against SARS-CoV-2 in the hamster model, with significant reductions in viral load and improved lung pathology.<\/p>\n<\/li>\n<li>\n<p><strong>Pathway Analysis<\/strong>: Pathway and Mode of Action (MOA) analyses of differentially expressed genes were conducted to understand the mechanisms of action underlying the therapeutic efficacy observed.<\/p>\n<\/li>\n<\/ul>\n<p>This summary captures the ethical approvals, patient and animal study details, drug screening processes, and key findings from the study.<\/p>\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Evaluation of artificial intelligence identified ipratropium bromide for the treatment of coronavirus disease 2019 https:\/\/www.nature.com\/articles\/s41598-025-27869-y&#8230;<\/p>\n","protected":false},"author":1,"featured_media":188812,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/media.springernature.com\/m685\/springer-static\/image\/art%3A10.1038%2Fs41598-025-27869-y\/MediaObjects\/41598_2025_27869_Fig1_HTML.png","fifu_image_alt":"","footnotes":""},"categories":[14],"tags":[20],"class_list":["post-188811","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artificial-intelligence","tag-artificial-intelligence"],"_links":{"self":[{"href":"https:\/\/testing.news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts\/188811"}],"collection":[{"href":"https:\/\/testing.news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/testing.news-you-need.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/testing.news-you-need.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/testing.news-you-need.com\/index.php\/wp-json\/wp\/v2\/comments?post=188811"}],"version-history":[{"count":1,"href":"https:\/\/testing.news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts\/188811\/revisions"}],"predecessor-version":[{"id":188813,"href":"https:\/\/testing.news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts\/188811\/revisions\/188813"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/testing.news-you-need.com\/index.php\/wp-json\/wp\/v2\/media\/188812"}],"wp:attachment":[{"href":"https:\/\/testing.news-you-need.com\/index.php\/wp-json\/wp\/v2\/media?parent=188811"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/testing.news-you-need.com\/index.php\/wp-json\/wp\/v2\/categories?post=188811"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/testing.news-you-need.com\/index.php\/wp-json\/wp\/v2\/tags?post=188811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}